Purine nucleoside analogs in the therapy of cancer and neuroinflammation

Effect of Purine Nucleoside Analogue-Acyclovir on The Sperm Parameters and Testosterone Production in Rats

Changes in sarcoma 180 cells associated with drug-induced resistance to adenosine analogs.

pentenyl)adenosine (IPAR). The resistance was unaltered after 5 months maintenance in absence of the drug. S-180/KR cells showed increased sensitivity to certain purine and pyrimidine nucleoside analogs such as 6-thiopurine ribonucleoside and 5-fluorodeoxyuridine. The activity of purine nucleoside phosphorylase (purine nucleoside:orthophosphate ribosyltransferase, EC 2.4.2.1) an enzyme that in ...

Growth Inhibition of Clostridium Feseri by Carcinostatic Purine and Pyrimidine Analogs. I. Effect of Medium on Growth Inhibition.

Clostridium feseri (chuavoei), ATCO-10092, grows well in a semi-synthetic basal medium devoid of purine bases and folic acid. Growth inhibition of this organism in such a medium by carcinostatic purine analogs is pronounced, and by pyrimidine analogs marked. Purines in the medium block the growth inhibition of Clostridium feseri by purine analogs. Greater agreement occurs between the growth inh...

5'-Nucleotides as potential formulations for administering nucleoside analogs in man.

A variety of nucleoside analogs have shown carcinostatic activity. In some instances they are relatively rapidly excreted. In others they are relatively rapidly inactivated in vivo by catabolic enzymes. In both cases it appeared desirable to have nucleoside derivatives that would act as depot forms of the nucleoside analogs and would be converted in vivo to the respective nucleoside analog. Gis...

Selective abolishment of pyrimidine nucleoside kinase activity of herpes simplex virus type 1 thymidine kinase by mutation of alanine-167 to tyrosine.

Herpes simplex virus type 1 (HSV-1) encodes a thymidine kinase (TK) that markedly differs from mammalian nucleoside kinases in terms of substrate specificity. It recognizes both pyrimidine 2'-deoxynucleosides and a variety of purine nucleoside analogs. Based on a computer modeling study and in an attempt to modify this specificity, an HSV-1 TK mutant enzyme containing an alanine-to-tyrosine mut...